There is much to say on this topic but,,

I have been using BIOCHEMIC PHOSPHATES by Hyland's for quite awhile as Toby's behavior has become more agressive and he is more irritable (this is putting this mildly at times).   With one or more doses of these, I usually find it helps him to relax.  I have also used the "Stress" formula by another brand with decent results.

I also use it for Coleman and Emily when it seems appropriate.