You can not lose your salvation but you can lose rewards in heaven for our deeds on Earth.

“But he that doeth wrong shall receive for the wrong which he hath done: and there is no respect of persons.”
Colossians 3:25

This portion of the Word of God is teaching about the relationship between servants and masters. Servants are taught to obey their masters with the right heart attitude, serving as unto the Lord and not unto men. The servant who thus performs his duty is promised a just reward from the Lord. God will righteously reward those who are faithful in their service and obey Him and others. However, those who do not obey will also be compensated. The context ends with our text, “But he that doeth wrong shall receive for the wrong which he hath done.” Wrongs that are not properly made right will result in definite retribution. We should all be thankful that Christ died on the cross for our sins, that we might be forgiven through the mercy of God the moment we trust Christ as Savior. We are likewise promised that when we sin, after we are born again, we can confess that sin to God and receive His gracious forgiveness. However, the same Bible that reveals these glorious truths also teaches us that God is a just Judge, and God Almighty will one day judge wrongs that are not made right. One day, we will stand before the Judgment Seat of Christ and give account for the deeds that we have done. Too many people choose to ignore this aspect of God’s justice. They live as though they can disobey God’s Word and never suffer any consequences or chastisement. Many seem to believe that God is always ready to reward good deeds, but is somehow unconcerned about “he that doeth wrong.” But the Bible teaches otherwise. The same God who rewards the doing of right, also rewards the doing of wrong. One may do wrong and somehow avoid being detected by others, “But he that doeth wrong shall receive for the wrong which he hath done.” God sees everyone and everything, and He will punish for acts of rebellion, regardless of who it is. “There is no respect of persons” with God. The fact that God recognizes and blesses the right choices and also judges wrong actions should motivate us to live in such a way as to please Him. We ought to be reminded that sin is serious and must be dealt with properly. Galatians 6:7 tells us, “Be not deceived; God is not mocked: for whatsoever a man soweth, that shall he also reap.”